Our research involves synergistic actuation strategies that combine and augment the outcomes of substrate nano-patterning, opto-magnetic stimulation, and smart nanovector modulation on intracellular pathways. The ongoing research is situated at the interface of mechatronics, medicine, physics, biochemistry and biotechnology. Mechanical and Biomedical engineering concepts and the design and characterization techniques, especially in the area of sensing, device fabrication, advanced material performance, nanofluidics, nano-scale force and temperature regulation and nano-scale heat transfer play a crucial role in the success of these multidisciplinary research endeavors.

Primarily, we are focused in the area of neural circuit reconstruction after central nervous system injury, and chronic wound care. To this end, we are currently pursuing four research projects: (a) controlled release of nerve growth factors in neuronal cells by smart nanostructures for neurite outgrowth; (b) photo-magnetic stimulation of neurons to promote neurite outgrowth and differentiation of pluripotent stem cells; (c) molecular level opto-magnetic battery design for ATP synthesis regulation, and (d) on demand delivery of the combination drugs to the targeted wound site by unique combination of opto-magnetic actuation and bio-degradable nano-carriers.

The impact of these endeavors is to develop and implement increased learning in nanoscience and bioengineering for the next generation of scientists and engineers who will lead discovery at the nanoscale. It has the potential to serve as a model for other mid-size institutions like our own that wish to impact the education of undergraduate and graduate engineering students in areas of emerging technologies.

Team

Dr. Santaneel Ghosh, Ph.D

Group Leader

Dr.Santaneel Ghosh is currently serving as an Associate Professor in the Department of Physics and Engineering Physics at Southeast Missouri State University, Cape Girardeau, MO. He is also a visiting faculty at the Nanotechnology Research Center, University of Texas at Arlington, TX. He has received his Ph.D in Mechanical Engineering from the University of Arizona, Tucson, in 2005. During doctoral study, he has conducted research on design and development of the lead-free solders for semiconductor industries. During postdoctoral training, he has performed research on multifunctional nanostructure synthesis and characterization for therapeutic applications.

His research interests are: remotely tunable nanostructure design for targeted delivery and axon-regeneration after nervous system injury, opto-magnetic combination therapy for tumor regression, hydrogel encapsulated quantum dots for single cell imaging, and smart nanostructure design for energy applications. So far, he has published more than 30 articles in reputed journals and international conference proceedings.

He served as a reviewer for the National Institute of Health (NIH), American Chemical Society (ACS), and many internationally reputed journals. He was the recipient of the following awards:

  1. “Cottrell College Science Award” for young faculties - Research Corporation for Science Advancement, Tucson, Ariz.;
  2. “Faculty Research Award,” Southeast Missouri State University, 2010;
  3. “Tony B. Award,” Association of laboratory Automation, 2010, 2011; and
  4. Center of Nanoscale Science and Technology-University of Maryland, College Park (CNST-UMD) Scholarship, 2009-2015.

sghosh@semo.edu
(573)651-2393

Siddhartha Mukherjee

Graduate Assistant

I am a Graduate student majoring in Environmental Science and my secondary area of research is Nano-Bio engineering and cell biology, I am working in the neuronal circuit genaretion and neurite outgrowth. My research interest includes the study and development of novel Pc-12 cell line ( a model neuronal cell from Adrenbal cortex of Rat ) and control cellular activity using optogenetic stimulation, and the neurite development using optical irradiation (using LED Exposure.) Further, I will be shooting for my P.hD in the same cellular biology field relating to the neuronal cell line.

Saddam Al Amin

Undergradute student

Saddam Al Amin is majoring in Physics with a minor in mathematics. He is an undergraduate student working bio-marker project with Dr. Santaneel Ghosh. He is also working on a project named "High Altitude Baloon project" with Varun Sadaphal and Colten Peterson. Along with that he has programming skills on VPython , PHP, JavaScript, SQL, and some basic skills on web development.

(571)499-2969
lisanalamin@gmail.com

Edward Strauser

Undergradute student

Engineering-Physics: Mechanical Applications major with a minor in mathematics. My areas of research include quantum dots, aerogels, quinine bio-markers & ferromagnetic nanoparticle synthesis as well as micro-fluidic chip design for photomagnetic nanoparticle excitation device.

Rahul Armani

Undergradute student
Biomedical sciences major, with a minor in physics and chemistry. My research focus is in regenerative and systems neuroscience and developing cancer therapeutic models. In addition, I have been involved in ferromagnetic particle synthesis, characterizing modalities of nanotaxterure substrates, and carbon nanotubes. Currently, I am studying GAP 43 expression in neural model cells subject to optical/NGF stimulation in the presence of high functionality nano-textured substrates.

Tharaka

Undergradute student

Collaborators

Internal

  • Dr. Jai N. Dahiya,Southeast Missouri State University.
  • Dr. Jian Peng, Southeast Missouri State University.
  • Dr. Vijay Anand, Southeast Missouri State University.
  • Dr. Fazel Kesther, Southeast Missouri State University.

External

  • Dr. DiAnna L. Hynds, Texas Woman’s University.
  • Dr. Nathaniel Mills, Texas Woman’s University.
  • Dr. Tae Youl Choi, University of North Texas.
  • Dr. Naushad Ali, Southern Illinois University.
  • Dr. David Diercks, Colorado School of Mines.
  • Dr. Kerry Sebain, CNST-NIST, Washington, DC.
  • Dr. Samir Iqbal, University of Texas at Arlington.

Industry

  • Dr. Cosmin Radu, Lakeshore Inc.

News

  • Southeast Engineering Professor Pioneering Device to Assess Health, Stress of USAF Service Members
  • Work of Southeast Professor Appears in Prestigious Scientific Journal
  • Physics Professor Wins Cottrell College Science Award to Conduct Nano-Biotechnology Research
  • Adam Northcutt recieves Honorable Mention Award for National Science Foundation Graduate Research Fellowship Program research proposal
    • Adam Northcutt, a Ph.D. candidate at the University of Missouri-Columbia, recently received an Honorable Mention Award for his National Science Foundation Graduate Research Fellowship Program research proposal. As a research student in Dr. David Schulz’s Lab, Norhtcutt’s proposed work involved preforming a deep sequencing of the RNA found in the Major Pelvic Ganglion, a group of neurons that control bladder function, in order to determine the molecular characteristics of the sympathetic and parasympathetic cell types found there. When an individual loses bladder control, such as after a spinal cord injury or pregnancy, changes in the properties of these neurons could be partly to blame, so understanding them in detail is critical to discovering potential therapeutic targets for alleviating lost urinary function.

Nano Course Complettion Certificate

This certification will be issued to undergraduate and graduate students as well as to the other certification pursuing person(s) based on their eligibility and successful completion of the courses

Location
Polytechnic Building 216
Mailing Address
One University Plaza, MS 6825
Cape Girardeau, MO 63701