Our research involves synergistic actuation strategies that combine and augment the outcomes of substrate nano-patterning, opto-magnetic stimulation, and smart nanovector modulation on intracellular pathways. The ongoing research is situated at the interface of mechatronics, medicine, physics, biochemistry and biotechnology. Mechanical and Biomedical engineering concepts and the design and characterization techniques, especially in the area of sensing, device fabrication, advanced material performance, nanofluidics, nano-scale force and temperature regulation and nano-scale heat transfer play a crucial role in the success of these multidisciplinary research endeavors.

Primarily, we are focused in the area of neural circuit reconstruction after central nervous system injury, and chronic wound care. To this end, we are currently pursuing four research projects: (a) controlled release of nerve growth factors in neuronal cells by smart nanostructures for neurite outgrowth; (b) photo-magnetic stimulation of neurons to promote neurite outgrowth and differentiation of pluripotent stem cells; (c) molecular level opto-magnetic battery design for ATP synthesis regulation, and (d) on demand delivery of the combination drugs to the targeted wound site by unique combination of opto-magnetic actuation and bio-degradable nano-carriers.

The impact of these endeavors is to develop and implement increased learning in nanoscience and bioengineering for the next generation of scientists and engineers who will lead discovery at the nanoscale. It has the potential to serve as a model for other mid-size institutions like our own that wish to impact the education of undergraduate and graduate engineering students in areas of emerging technologies.

 

Meet the Team

Meet the Nano-Bio Laboratory Team

Ongoing Research Projects

  • Design of Nanoscale Intracellular Stress Detector for Deep-Space Exploration Missions
  • Hybrid Photo-Magnetic Field Generator Design for Assessment of Nanoscale Materials and Therapeutic Molecules
  • Fabrication of novel micro-fluidic devices for controlled release of therapeutic agents
  • Externally tunable, smart nanostructure and nano-substrates design for drug delivery to facilitate damaged neural circuit reconstruction  

Collaborators

Internal

  • Dr. Jai N. Dahiya,Southeast Missouri State University
  • Dr. Jian Peng, Southeast Missouri State University
  • Dr. Vijay Anand, Southeast Missouri State University
  • Dr. Fazel Kesther, Southeast Missouri State University

External

  • Dr. DiAnna L. Hynds, Texas Woman’s University
  • Dr. Nathaniel Mills, Texas Woman’s University
  • Dr. David Diercks, Colorado School of Mines
  • Dr. Somesree Mitra, University of Texas Southwestern Medical Center
  • Dr. Kakkattukuzhy Isaac, Missouri S&T

Industry

  • Dr. Cosmin Radu, Lakeshore Inc.

Publications

Patents

  • Ghosh, S., Peng, J., and GhoshMitra, S., Methods and Device for Simultaneous Optical Irradiation and Oscillating Magnetic Field Radiation of a Target (Granted US Patent Number: 11046947, 2021).

  • Ghosh, S., and GhoshMitra, S., Multimodal Therapy for Cancer Cell Destruction (Granted US Patent Number: 11077191, 2021).

  • Ghosh, S., Sadaphal, V., and Petersen, C., Photo-Magnetic Actuation Device for Suspended Nanostructures in Flowing Fluid (US Patent Application Serial Number: 62/937,039, 2021)

  • Ghosh, S., and GhoshMitra, S., Multimodal Therapy for Cancer Cell Destruction (Divisional US Patent Application Serial Number: 17/305,103, 2021).

Journal Articles

  • Atluri R., Atmaramani R., Tharaka G., McCallister T., Peng J., Diercks D., GhoshMitra S., and Ghosh S., Photo-magnetic irradiation mediated multimodal therapy of neuroblastoma cells using cluster of multifunctional nanostructures, Nanomaterials, Vol. 8 (10), 2018.

  • Sadaphal V., Mukherjee S., and Ghosh S., Hybrid photomagnetic modulation of magnetite/gold-nanoparticle-deposited dextran-covered carbon nanotubes for hyperthermia applications, Applied Physics Express, Vol. 11, 097001, 2018.

  • GhoshMitra S., and Ghosh, S., A novel nano-structure for central nervous system drug delivery: sustained release of therapeutic agents from core-multi-shell nano-carriers, JSM Nanotechnol Nanomed 4(1):1040, 2016.

  • Islam M., Atmaramani R., Mukherjee S., Ghosh S., and Iqbal S., Enhanced proliferation of PC12 neural cells on untreated, nanotextured glass coverslips, Nanotechnology, Vol. 27, No. 41, 2016.

  • McCallister T., Gidney, E., Adams, D., Diercks, D., and Ghosh, S., Engineering thermoresponsive, magnetic nanocarriers of oligo(ethylene glycol)-methacrylate-based biopolymers (Applied Physics Express, Vol. 7, 2014, 117003).

  • Roberts, J., Dahiya, J., Ghosh, S., Using a microwave resonant cavity to study hydrogen bonding at phase transition in H2O and D2O, (International Journal of Microwave and Optical Technology, Vol. 9, No. 2, 2014, pp. 183-190).

  • GhoshMitra, S., Diercks, D., Mills, N., Hynds, D., and Ghosh, S., Moderate level exposure to poly(ethylene glycol) analouge biopolymer encapsulated, multifunctional magnetic nanodots do not deleteriously affect neuite outgrowth, Journal of Nanoscience and Nanotechnology, 2013, Vol.13, pp. 8290-8297.

  • GhoshMitra, S., Diercks, D., Mills, N., Hynds, D., and Ghosh, S., Role of engineered nanocarriers for axon regeneration and guidance: current status and future trends, Advanced Drug Delivery Reviews, 2012, doi:10.1016/j.addr.2011.12.013.

  • GhoshMitra, S., Diercks, D., Mills, N., Hynds, D., and Ghosh, S., Excellent biocompatibility of semiconductor quantum dots encased in multifunctional poly(N-isopropylacrylamide) nano-reservoirs and nuclear specific labeling of growing neurons, Applied Physics Letters, Vol. 98, 103702 (2011); doi:10.1063/1.3562036 (3 pages).

  • Ghosh. S, and Cai., T., “Controlled actuation of alternating magnetic field-sensitive tunable hydrogels”, Journal of Physics D: Applied Physics, Vol. 43, No. 41, 2010,415504(10 pp).

  • GhoshMitra, S., Cai, T., Diercks, D., Hu, Z., Roberts, J., Dahiya, J., Mills, N., Hynds, D., and Ghosh, S., Evaluation of the biological effects of externally tunable, hydrogel encapsulated quantum dot nanospheres in Escherichia coli, Polymers, Vol. 3, 2011, 1243-1254.

  • Ghosh, S., GhoshMitra, S., Cai, T., Diercks, D., Mills, N., and Hynds, D., Alternating magnetic field controlled, multifunctional nano-reservoirs: Intracellular uptake and improved biocompatibility, Nanoscale Research Letters, Vol. 5, No. 1, 2010, pp. 195-204. [*Snapshot from this work won AAPS-NBC 2009 Travelship award, Biotechnology Section]

  • Ghosh, S., Yang, C., Cai, T. Hu, Z., and Neogi, A., Oscillating magnetic field-actuated microvalves for micro- and nanofluidics. Journal of Physics D: Applied Physics, Vol. 42, No. 13, 2009,135501(8 pp).

  • Garner, B., Cai, T., Ghosh, S., Hu, Z., and Neogi, A., Refractive Index Change Due to Volume-Phase Transition in Polyacrylamide Gel Nanospheres for Optoelectronics and Bio-photonics, Applied Physics Express, Vol. 2, No. 5, 2009, 057001(3 pp).

  • Dahiya, J. N, Ghosh, S., and Roberts, J “A computer controlled microwave spectrometer for dielectric relaxation studies of polar molecules”, International Journal of Microwave and Optical Technology, Vol. 5, No. 6, 2010, pp. 384-389.

  • Dahiya, J. N, Ghosh, S., Anand. A. and Roberts, J “A Computer Controlled Microwave Resonant Cavity used for the Dielectric Studies of Liquid Crystals”, International Journal of Microwave and Optical Technology, Vol. 4, No. 3, 2009, pp. 149-152.

  • Kay, N. R., Ghosh, S., Guven, I., and Madenci, E., 2006, “A Combined Experimental and Analytical Approach for Interface Fracture Parameters Between Dissimilar Materials in Electronic Packages,” Journal of Material Science and Engineering, Vol. 421, pp.57-67.

News

  • Southeast Engineering Professor Pioneering Device to Assess Health, Stress of USAF Service Members
  • Work of Southeast Professor Appears in Prestigious Scientific Journal
  • Physics Professor Wins Cottrell College Science Award to Conduct Nano-Biotechnology Research
  • Adam Northcutt recieves Honorable Mention Award for National Science Foundation Graduate Research Fellowship Program research proposal
    • Adam Northcutt, a Ph.D. candidate at the University of Missouri-Columbia, recently received an Honorable Mention Award for his National Science Foundation Graduate Research Fellowship Program research proposal. As a research student in Dr. David Schulz’s Lab, Norhtcutt’s proposed work involved preforming a deep sequencing of the RNA found in the Major Pelvic Ganglion, a group of neurons that control bladder function, in order to determine the molecular characteristics of the sympathetic and parasympathetic cell types found there. When an individual loses bladder control, such as after a spinal cord injury or pregnancy, changes in the properties of these neurons could be partly to blame, so understanding them in detail is critical to discovering potential therapeutic targets for alleviating lost urinary function.

Nano Course Complettion Certificate

This certification will be issued to undergraduate and graduate students as well as to the other certification pursuing person(s) based on their eligibility and successful completion of the courses

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Location
Polytechnic Building 216
Mailing Address
One University Plaza, MS 6825
Cape Girardeau, MO 63701