Best Pizza in Cape Girardeau, Mo | SEMO

As luck would have it, most of the best pizza places happen to be located on Broadway or a short drive from SEMO. So, if you’re looking for the best pizza that is close to campus – here are your best options. 

BEST SPECIALTY PIZZA / ENCORE PIZZERIA + KITCHEN  

46 N Main St, Cape Girardeau, MO 63701 / 573.381.5477 

Are you wanting a pizza place with one-of-a-kind specialties? Encore Pizzeria + Kitchen is your best choice here in Cape Girardeau. They offer a warm and welcoming environment and serve incredible, handmade pizza like pepperoni hot honey, and other Italian-inspired cuisine like chicken fried potatoes and gnocchi.

The pepperoni hot honey pizza is a good option for those who want to try something classic. While you may not consider it a “specialty” pizza, it becomes one when you take a bite of it. It consists of tomato sauce, mozzarella, charred pepperoni, parmesan, and, specifically, house-made hot honey.  

Another specialty pizza to highlight is the Hot Tropic. If you like pineapple on your pizza, this one is definitely for you. Toppings include charred pepperoni, pineapple, and hot honey.  

Don’t worry, they have other options that do not include pineapple, like the quattro meat pizza, consisting of pepperoni, Italian sausage, bacon, and capocollo. The Shaved & Confused is also a go-to option, served with alfredo, smoked shaved sirloin, mozzarella, and crispy fried onion. 

THE LOCALS’ FAVORITE / PAGLIAI’S PIZZA 

1129 Broadway, Cape Girardeau / 573.335.0366 

Established in 1968, Pagliai’s Pizza has been a favorite among locals for quite some time. Their hand-crafted pizzas come in a variety of crust options including their classic signature thin crust as well as offering thick, wheat and gluten-free options! Whether you opt for a classic pizza or decide to try the Pagliai’s Special, you really can’t go wrong here! 

Unfortunately, Pagliai’s is no longer open at lunch, so plan on here for dinner only!  

BEST ALL-AROUND PIZZA / SPECK PIZZA + STREET FOOD 

430, Broadway, Cape Girardeau / 573-419-4326 

Speck is inspired by the street food vendors of Europe. They focus on clean organic ingredients while holding an emphasis on bold flavors. Most of their ingredients are imported from Italy, making Speck unlike any other restaurant Cape Girardeau.  

They have plenty of Italian dishes and an extensive list of pizza options. Their signature pizza, the Speck Pizza, is a fan favorite. This pizza has a whipped ricotta cheese base and comes with mozzarella, speck, arugula, balsamic, candied walnuts, and shaved parmesan on top.    

BEST CHAIN PIZZA PLACE / IMO’S PIZZA 

1008 N Kingshighway St, Cape Girardeau / 573.334.3993 

While Imo’s is technically a “chain” pizza place, it sure tops above the other chains. If you’re from St. Louis, then you probably already know about them. Maybe having an Imo’s Pizza in town will help you feel a little closer to home while you’re here! 

Imo’s is famous for their St. Louis style square-cut pizza; their thin, crispy crust pizza has a homemade sauce, Provel cheese and fresh toppings. They offer awesome lunch specials during the week, so you can get a small or individual size pizza for much less.  

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