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Directions from St. Louis / Cape Girardeau (via I-55):
Take I-55 South towards Sikeston, Take exit 66B to merge onto US-60 W toward Dexter/Poplar Bluff, Take the exit toward US-67 Bus/Poplar Bluff, Merge onto Hwy 67 N/US-60/US-67 and continue to follow US-60/US-67, Turn right at Pinecrest Drive. Pinecrest Drive becomes Three Rivers Boulevard.
Directions from Springfield (via US-60):
Take US-60 E towards Cabool for about 82 miles. Continue on US-60 E/US-67 for about 90 miles. Take the ramp onto US-60 BUS E/US-67 BUS S. Follow for about 6 miles, then turn right onto Three Rivers Boulevard (by the Fazoli's restaurant). (3.5 Hours Drive Time)
Directions from Jonesboro (via US-63/US-67):
Take US-63 N for about 22 miles, Take the ramp onto US-67 and continue for about 27 miles, Take the MO-PP exit toward Poplar Bluff, Turn right at Kanell Boulevard/MO-PP/MO-Y, Turn left at Herschel Bess Boulevard, Herschel Bess Boulevard turns into Three Rivers Boulevard. (2 Hours Drive Time)