Our research involves synergistic actuation strategies that combine and augment the outcomes of substrate nano-patterning, opto-magnetic stimulation, and smart nanovector modulation on intracellular pathways. The ongoing research is situated at the interface of mechatronics, medicine, physics, biochemistry and biotechnology. Mechanical and Biomedical engineering concepts and the design and characterization techniques, especially in the area of sensing, device fabrication, advanced material performance, nanofluidics, nano-scale force and temperature regulation and nano-scale heat transfer play a crucial role in the success of these multidisciplinary research endeavors.
Primarily, we are focused in the area of neural circuit reconstruction after central nervous system injury, and chronic wound care. To this end, we are currently pursuing four research projects: (a) controlled release of nerve growth factors in neuronal cells by smart nanostructures for neurite outgrowth; (b) photo-magnetic stimulation of neurons to promote neurite outgrowth and differentiation of pluripotent stem cells; (c) molecular level opto-magnetic battery design for ATP synthesis regulation, and (d) on demand delivery of the combination drugs to the targeted wound site by unique combination of opto-magnetic actuation and bio-degradable nano-carriers.
The impact of these endeavors is to develop and implement increased learning in nanoscience and bioengineering for the next generation of scientists and engineers who will lead discovery at the nanoscale. It has the potential to serve as a model for other mid-size institutions like our own that wish to impact the education of undergraduate and graduate engineering students in areas of emerging technologies.